Climate indicators related to Long Island Sound (LIS) water and air temperature variability were investigated. The Pacific decadal oscillation (PDO) and east Pacific/North Pacific (EP/NP) patterns are found to be strongly correlated with LIS air temperature anomalies during most seasons, especially during the winter. Additionally, the winter EP/NP index is strongly correlated with subsequent spring and summer LIS water temperature anomalies, potentially rendering the EP/NP index useful in extended LIS water temperature outlooks. Such lagged relationships are found to be related largely to the decorrelation time scale of seasonal water temperature anomalies. The atmospheric circulation pattern associated with anomalous LIS water temperature conditions is consistent with atmospheric Rossby wave trains emanating from the western equatorial Pacific. The EP/NP index has a characteristic time scale of approximately 5 to 10 years and such fluctuations are termed the quasi-decadal mode, the mode identified as varying coherently with LIS air and water temperature anomalies. Apparent PDO and EP/NP regime shifts in 1997 are found to coincide with a LIS water temperature regime shift. This result suggests that not all LIS warming experienced during recent decades is solely due to anthropogenic causes but rather is to some extent a result of natural variability. The results from this study provide a useful framework for both seasonal and decadal prediction of LIS water temperature variability.